1. Березин Д.Б. - отзыв
2. Велегжанинов И.О. - отзыв
3. Клапшина Л.Г - отзыв
4. Кузнецова Д.С. - отзыв
5. Петрова Д.В. - отзыв
6. Сироткина М.А. - отзыв
7. Турубанова В.Д. - отзыв

Адрес: 420008, Россия, г. Казань, ул. Кремлевская, д.18, тел. +7 (843) 939-29-03, public.mail@kpfu.ru, https://kpfu.ru/

Список основных публикаций работников ведущей организации по теме диссертации в рецензируемых научных изданиях за последние 5 лет:
1. Davidovich P., Nikolaev D., Khadiullina R., Gurzhiy V., Bulatov E. Cyclic vinyl sulfones activate NRF2 to protect from oxidative stress-induced programmed necrosis // Bioorganic and Medicinal Chemistry Letters. – 2025. – Vol. 117. – DOI: 10.1016/j.bmcl.2024.130058.
2. Boichuk S., Dunaev P., Skripova V., Galembikova A., Bikinieva F., Shagimardanova E., Gazizova G., Deviatiiarov R., Valeeva E., Mikheeva E., Vasilyeva M., Kopnin P. Unraveling the mechanisms of sensitivity to anti-FGF therapies in imatinib-resistant gastrointestinal stromal tumors (GIST) lacking secondary KIT mutations // Cancers (Basel). – 2023. – Vol. 15 (22). – DOI: 10.3390/cancers15225354.
3. Tsepaeva O.V., Salikhova T.I., Ishkaeva R.A., Kundina A.V., Abdullin T.I., Laikov A.V., Tikhomirova M.V., Idrisova L.R., Nemtarev A.V., Mironov V.F. Bifunctionalized betulinic acid conjugates with C-3-monodesmoside and C-28-triphenylphosphonium moieties with increased cancer cell targetability // Journal of Natural Products. – 2023. – Vol. 86(8). – P. 1939-1949. – DOI: 10.1021/acs.jnatprod.3c00304.
4. Stavitskaya A., Sitmukhanova E., Sayfutdinova A., Khusnetdenova E., Mazurova K., Cherednichenko K., Naumenko E., Fakhrullin R. Photoinduced antibacterial activity and cytotoxicity of CdS stabilized on mesoporous aluminosilicates and silicates // Pharmaceutics. – 2022. – Vol. 14 (7). – DOI: 10.3390/pharmaceutics14071309.
5. Skripova V., Vlasenkova R., Zhou Y., Astsaturov I., Kiyamova R. Identification of new regulators of pancreatic cancer cell sensitivity to oxaliplatin and cisplatin // Molecules. – 2022. – Vol. 27 (4). – DOI: 10.3390/molecules27041289.
6. Garipov K.A., Afanaseva Z.A., Abramova Z.I. On the role of autophagy in the progression of differentiated thyroid cancer // Siberian Journal of Oncology. – 2021. – Vol. 20 (6). – P. 134-140. – DOI: 10.21294/1814-4861-2021-20-6-134-140.
7. Nurgalieva A.K., Popov V.E., Skripova V.S., Bulatova L.F., Savenkova D.V., Vlasenkova R.A., Safina S.Z., Shakirova E.Zh., Filonenko V.V., Bogdanov M.V., Kiyamova R.G. Sodium-dependent phosphate transporter NaPi2b as a potential predictive marker for targeted therapy of ovarian cancer // Biochemistry and Biophysics Reports. – 2021. – Vol. 28. – DOI: 10.1016/j.bbrep.2021.101104.
8. Gorbachevskii M.V., Stavitskaya A.V., Novikov A.A., Fakhrullin R.F., Rozhina E.V., Naumenko E.A., Vinokurov V.A. Fluorescent gold nanoclusters stabilized on halloysite nanotubes: in vitro study on cytotoxicity // Applied Clay Science. – 2021. – Vol. 207. – DOI: 10.1016/j.clay.2021.106106.
9. Vlasenkova R., Nurgalieva A., Akberova N., Bogdanov M., Kiyamova R. Characterization of slc34a2 as a potential prognostic marker of oncological diseases // Biomolecules. – 2021. – Vol. 11(12). – DOI: 10.3390/biom11121878.
10. Rozhina E., Danilushkina A., Akhatova F., Fakhrullin R., Rozhin A., Batasheva S. Biocompatibility of magnetic nanoparticles coating with polycations using A549 cells // J Biotechnol. – 2021. – Vol. 325. – P. 25-34. – DOI: 10.1016/j.jbiotec.2020.12.003.
11. Mazitova A.M., Topchu Iu.A., Mingazova L.A., Biktagirova E.M., Abramova Z.I., Gabbasov R.T. Role of autophagy in response of epithelial ovarian cancer cells to cisplatin treatment and cisplatin resistance // Genes and Cells. – 2020. – Vol. 15(3). – P. 44-47. – DOI: 10.23868/202011006.
12. Tsepaeva O.V., Nemtarev A.V., Salikhova T.I., Abdullin T.I., Grigor Eva L.R., Khozyainova S.A., Mironov V.F. Synthesis, anticancer, and antibacterial activity of betulinic and betulonic acid C-28-triphenylphosphonium conjugates with variable alkyl linker length // Anticancer Agents Med Chem. – 2020. – Vol. 20(3). – P. 286-300. – DOI: 10.2174/1871520619666191014153554.

1. Мартынов Александр Германович, ведущий научный сотрудник лаборатории новых физико-химических проблем Федерального государственного бюджетного учреждения науки Институт физической химии и электрохимии им. А.Н. Фрумкина Российской академии наук (ИФХЭ РАН) (отзыв)
   
   

   Наименования отрасли науки, научной специальности, по которым оппонентом защищена диссертация:
   доктор химических наук, 02.00.04 – физическая химия, 02.00.01 – неорганическая химия

   Список основных публикаций официального оппонента по теме диссертации в рецензируемых научных изданиях за последние 5 лет:
   1. Kroitor A.P., Dmitrienko A.A., Kirakosyan G.A., Lorentz C., Martynov A.G., Gorbunova Yu.G., Tsivadze A.Yu., Sorokin A.B. Designing ruthenium phthalocyanine with chiral pockets formed by (1R,2S,5R)-menthoxy groups for enantioselective catalysis // ACS Catalysis. – 2025. – Vol. 15. – Is. 6. – P. 4984–5001. – DOI: 10.1021/acscatal.4c07696.
   2. Bunin D.A., Akasov R.A., Martynov A.G., Stepanova M.P., Monich S.V., Tsivadze A.Yu., Gorbunova Yu.G. Pivotal role of the intracellular microenvironment in the high photodynamic activity of cationic phthalocyanines // Journal of Medicinal Chemistry. – 2025. – Vol. 68(1). – P. 658-673. – DOI: 10.1021/acs.jmedchem.4c02451.
   3. Spector D., Bykusov V., Isaeva Yu., Akasov R., Zharova A., Rodin I., Vokuev M., Grishin Yu., Nikitina V., Martynov A.G., Kuzmin V., Beloglazkina E. Green light activated dual-action Pt(IV) prodrug with enhanced PDT activity // ChemMedChem. – 2025. – DOI: 10.1002/cmdc.202400786.
   4. Efimova I.A., Safonova E.A., Polovkova M.A., Martynov A.G., Kirakosyan G.A., Tsivadze A.Yu., Gorbunova Yu.G. pH-Dependent molecular switch based on Pv porphyrin // Mendeleev Communications. – 2024. – Vol. 34(2). – P. 167-169. – DOI: 10.1016/j.mencom.2024.02.003.
   5. Spector D., Bykusov V., Zharova A., Kuzmichev I., Isaeva Y.A., Khaydukov E.V., Trifanova E., Stepanov M., Erofeev A.S., Gorelkin P., Kuanaeva R., Nikitina V.N., Dubenskii A., Maksimova Y., Skvortsov D.A., Ipatova D., Rodin I., Vokuev M.F., Martynov A.G., Bunin D.A., Pokrovsky V.S., Babayeva G., Uskova T., Abakumov M.A., Beloglazkina E.K., Akasov R.A., Krasnovskaya O.O. Nanoformulation of the photoactive cisplatin prodrug for combined photothermal therapy and bioimaging // ACS Applied Nano Materials. – 2024. – Vol. 7(22). – P. 25603 – 25618. – DOI: 10.1021/acsanm.4c04680.
   6. Monich S.V., Zhdanov A.P., Nelyubin A.V., Skribitsky V.A., Lipengolts A.A., Bunin D.A., Martynov A.G., Zhizhin K.Yu., Kuznetsov N.T., Gorbunova Yu.G., Tsivadze A.Yu. The first example of a polyhedral boron derivative of gadolinium(III) phthalocyaninate as a promising prototype of a theranostic agent // Inorganic Chemistry Communications. – 2024. – Vol. 167. – DOI: 10.1016/j.inoche.2024.112820.
   7. Dmitrienko A.A., Kroitor A.P., Bunin D.A., Arakcheev A.V., Martynov A.G., Selektor S.L., Tsivadze A.Yu., Gorbunova Yu.G. Tuning of the photophysical and electrochemical properties of ruthenium(II) phthalocyaninates by variation of axial ligands // Journal of Coordination Chemistry. – 2024. – Vol. 77(11). – P. 1220 – 1235. – DOI: 10.1080/00958972.2024.2352485.
   8. Yagodin A.V., Mikheev I.A., Bunin D.A., Sinelshchikova A.A., Martynov A.G., Gorbunova Yu.G., Tsivadze A.Yu. Tetraquinoxalinoporphyrazine – π-extended NIR-absorbing photosensitizer with improved photostability // Dyes and Pigments. – 2023. – Vol. 216. – DOI: 10.1016/j.dyepig.2023.111326.
   9. Shepeleva I.I., Birin K.P., Polivanovskaia D.A., Martynov A.G., Shokurov A.V., Tsivadze A.Yu., Selektor S.L., Gorbunova Yu.G. Unusual ‘turn-on’ ratiometric response of fluorescent porphyrin-pyrene dyads to the nitroaromatic compounds // Chemosensors. – 2023. – Vol. 11(1). – DOI: 10.3390/chemosensors11010043.
   10. Martynov A.G., Polovkova M.A., Gorbunova Yu.G., Tsivadze A.Yu. Redox-triggered switching of conformational state in triple-decker lanthanide phthalocyaninates // Molecules. – 2022. – Vol. 27(19). – DOI: 10.3390/molecules27196498.
   11. Gvozdev D.A., Solovchenko A.E., Martynov A.G., Yagodin A.V., Strakhovskaya M.G., Gorbunova Yu.G., Maksimov E.G. Fluorescence quenching of carboxy-substituted phthalocyanines conjugated with nanoparticles under high stoichiometric ratios // Photonics. – 2022. – Vol. 9(9). – DOI: 10.3390/photonics9090668.
   12. Gorbunova Yu.G., Martynov A.G., Birin K.P., Tsivadze A.Yu. NMR spectroscopy — a versatile tool for studying the structure and magnetic properties of paramagnetic lanthanide complexes in solutions // Russian Journal of Inorganic Chemistry. – 2021. – Vol. 66(2). – P. 202-216. – DOI: 10.1134/S0036023621020091.
   13. Birin K.P., Abdulaeva I.A., Polivanovskaia D.A., Martynov A.G., Shokurov A.V., Gorbunova Yu.G., Tsivadze A.Yu. Imidazoporphyrins with appended polycyclic aromatic hydrocarbons: To conjugate or not to conjugate? // Dyes and Pigments. – 2021. – Vol. 186. – DOI: 10.1016/j.dyepig.2020.109042.
   14. Martynov A.G., Polovkova M.A., Berezhnoy G.S., Sinelshchikova A.A., Dolgushin F.M., Birin K.P., Kirakosyan G.A., Gorbunova Yu.G., Tsivadze A.Yu. Cation-induced dimerization of heteroleptic crown-substituted trisphthalocyaninates as revealed by X-ray diffraction and NMR spectroscopy // Inorganic Chemistry. – 2020. – Vol. 59(13). – P. 9424-9433. – DOI: 10.1021/acs.inorgchem.0c01346.

2. Генина Элина Алексеевна, профессор кафедры оптики и биофотоники Института физики Федерального государственного бюджетного образовательного учреждения высшего образования «Саратовский национальный исследовательский государственный университет имени Н.Г. Чернышевского» (отзыв)
   
   

   Наименования отрасли науки, научной специальности, по которым оппонентом защищена диссертация:
   доктор физико-математических наук, 03.01.02 – биофизика

   Список основных публикаций официального оппонента по теме диссертации в рецензируемых научных изданиях за последние 5 лет:
   1. Svenskaya Y.I., Verkhovskii R.A., Zaytsev S.M., Lademann J., Genina E.A. Current issues in optical monitoring of drug delivery via hair follicles // Advanced Drug Delivery Reviews. - 2025. – Vol. 217(2). – DOI: 10.1016/j.addr.2024.115477.
   2. Surkov Y., Timoshina P., Serebryakova I., Stavtcev D., Kozlov I., Piavchenko G., Meglinski I., Konovalov A., Telyshev D.,
   Kuznetcov S., Genina E., Tuchin V. Laser speckle contrast imaging with principal component and entropy analysis: a novel approach for depth-independent blood flow assessment // Frontiers of Optoelectron. – 2025. – Vol. 18(1). – DOI: 10.1007/s12200-024-00143-1.
   3. Genina E.A., Lazareva E.N., Surkov Yu.I., Serebryakova I.A., Shushunova N.A. Optical parameters of healthy and tumor breast tissues in mice // Journal of Biophotonics. – 2024. – Vol. 17(8). – DOI: 10.1002/jbio.202400123.
   4. Bucharskaya A. B., Navolokin N. A., Mudrak D. A., Maslyakova G. N., Khlebtsov B. N., Khlebtsov N. G., Genin V. D., Genina E. A., Tuchin V. V. Photodynamic and plasmonic photothermal combination therapy of transplanted tumors of a rat model // Biophysics. – 2024. – Vol. 69(3). – P. 559-565. – DOI: 10.1134/S0006350924700623.
   5. Genin V.D., Bucharskaya A.B., Kirillin M.Y., Kurakina D.A., Navolokin N.A., Terentyuk G.S., Khlebtsov B.N., Khlebtsov N.G., Maslyakova G.N., Tuchin V.V., Genina E.A. Monitoring of optical properties of tumors during laser plasmon photothermal therapy // Journal of Biophotonics. – 2024. – Vol. 17(4). – DOI: 10.1002/jbio.202300322.
   6. Surkov Yu.I., Serebryakova I.A., Kuzinova Y.K., Konopatskova O.M., Safronov D.V., Kapralov S.V., Genina E.A., Tuchin V.V. Multimodal method for differentiating various clinical forms of basal cell carcinoma and benign neoplasms in vivo // Diagnostics. – 2024. – Vol. 14(2). – DOI: 10.3390/diagnostics14020202.
   7. Yanina I.Y., Genin V.D., Genina E.A., Mudrak D.A., Navolokin N.A., Bucharskaya A.B., Kistenev Y.V., Tuchin V.V. Multimodal diagnostics of changes in rat lungs after vaping // Diagnostics. – 2023. – Vol. 13 (21). – DOI: 10.3390/diagnostics13213340.
   8. Genin V.D., Bucharskaya A.B., Navolokin N.A., Terentyuk G.S., Khlebtsov B.N., Tuchin V.V., Genina E.A. Influence of immersion agents on optical parameters of bio-tissues during laser photothermal therapy of tumor: pilot study // Optics and Spectroscopy. – 2023. – Vol. 131(6). – P. 380-390. – DOI: 10.1134/S0030400X2302008X.
   9. Zaytsev S.M., Amouroux M., Tuchin V.V., Genina E.A., Blondel W. In vivo skin optical clearing efficacy quantification of clinically compatible agents using line-field confocal optical coherence tomography // Journal of Biomedical Optics. – 2023. – Vol. 28. – Is. 5. – DOI: 10.1117/1.JBO.28.5.055002.
   10. Genin V.D., Bucharskaya A.B., Terentyuk G.S., Khlebtsov N.G., Navolokin N.A., Tuchin V.V., Genina E.A. Changes in optical properties of model cholangiocarcinoma after plasmon-resonant photothermal treatment // Photonics. – 2022. – Vol. 9(3). – DOI: 10.3390/photonics9030199.
   11. Zaytsev S.M., Amouroux M., Khairallah G., Bashkatov A.N., Tuchin V.V., Blondel W. Genina E.A. Impact of optical clearing on ex vivo human skin optical properties characterized by spatially resolved multimodal spectroscopy // Journal of Biophotonics. – 2022. – Vol. 15(1). – DOI: 10.1002/jbio.202100202.
   12. Bucharskaya A.B., Khlebtsov N.G., Khlebtsov B.N., Maslyakova G.N., Navolokin N.A., Genin V.D., Genina E.A., Tuchin V.V. Photothermal and photodynamic therapy of tumors with plasmonic nanoparticles: Challenges and Prospects // Materials. – 2022. – Vol. 15(4). – DOI: 10.3390/ma15041606.
   13. Tichin V.V., Genina E.A., Tuchina E.S., Svetlakova A.V., Svenskay Yu.I. Optical clearing of tissues: issues of antimicrobial phototherapy and drug delivery // Advanced Drug Delivery Reviews. 2022. – Vol. 180(1). – DOI: 10.1016/j.addr.2021.114037.

10.04.2025 - Текст диссертации размещён в сети Интернет

21.04.2025 - Диссертация принята к защите (протокол № 8)